Systemic – born out of a deep desire to bring our vision to life, to create something authentic and to craft pieces that embody timelessness and individuality. SYSTEMIC definition: 1. A systemic drug, disease, or poison reaches and has an effect on the whole of a body or a plant…. Learn more. The simple definition of SYSTEMIC is of or relating to an entire system. 1. of or pertaining to a system. 2. pertaining to, affecting, or circulating through the entire body: systemic disease; systemic pesticide. Systematic and systemic both come from system. Systematic is the more common word; it most often describes something that is done according to a system or method. Systemic describes what relates to or affects an entire system, be that system physical, organizational, or societal. This disambiguation page lists articles associated with the title Systemic. If an internal link incorrectly led you here, you may wish to change the link to point directly to the intended article. Systemic refers to something that affects an entire system, like lack of transparency in a governing body. Systematic refers to an attribute of a process itself, specifically, that it is machine-like in its efficiency and organization. “Systemic” means affecting the entire body rather than a single spot. In medicine, a systemic condition, treatment, or reaction is one that travels through your bloodstream and reaches tissues and organs throughout your body, as opposed to staying in one localized area. Systemic means affecting the whole of something. The economy is locked in a systemic crisis. SYSTEMIC definition: of or relating to a system, especially when affecting the entirety of a thing. See examples of systemic used in a sentence.